it depends on the amp, some amps will have a switch on the rear channels to tell it where to pull signal, or a mode switch for the amp (2/3 channel mode or 4ch mode). Most nicer amps will have this switch. If it does not just get a pair of rca splitters and use them to send signal to both the front and rear channels.
If you get a 4channel LOC you can hook the rear channels to the rear speakers and then use the fader on your HU as a sub level control, which is always nice.
The remote wire needs to go to a wire in the car that shows 12v when the car is in acc mode, usually to the radio switched acc wire, or the cig lighter wire.